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Intermittent Fasting: A Dietitian's Review

One of the key difficulties with dieting and nutrition overall for many is trying to make sense of all the information available and determining what is right for you. Rather than giving yourself new food rules and choices to make, just eating within a specific time- thinking what when rather than what can seem so simple. For this reason, it’s easy to see why intermittent fasting (IF) has become so popular.


IF involves periods of alternating fasting and feasting. The fasting period typically lasts anywhere from 12 to 24 hours to be considered an intermittent fast. This is where some set rules do actually come into play.


There are two main types of IF:

  • Alternate day fasting: this is where you restrict your intake and fast for a few days per week. A common version of this is the 5:2 diet, where there are two non-consecutive days that you consume very low calories, and then eat normally for the remaining 5 days.

  • Time restricted feeding: this is where you shorten your eating window. By far the most common example, and often easiest to fit into someone’s day is the 16:8 diet. This involves an 8-hour window where you may eat and a 16 hour fast.

So, let’s get to the reason most people ask me about IF…weight loss


Weight Loss

To lose weight, you need to consume less energy than you burn to maintain your current weight and activity levels.


Generally, restricting your eating window, or overall intake may result in an overall calorie reduction, and so, weight loss. Quite consistently, IF has been found to be comparable to “traditional” calorie reduced diets when it comes to weight loss- not being any superior, faster, or easier to adhere to. This is also consistent in terms of measurements such as waist and hip circumference, and fat loss. The current findings regarding loss of fat free mass, including muscle varies.


In terms of adherence to IF does not seem to be superior and the evidence is mixed. Some studies have reported increased hunger reported by those following IF diets compared to standard calorie reduction, but even this isn’t consistent. Like with anything diet and lifestyle related, it very likely depends on and individual’s preferences and habits.


For some, the ideas of shortening their eating window works well and tends to fit their personal preferences e.g., those that feel unwell at the thought of eating breakfast (which I have written about before). For others, the delayed start, or even rules are eating times means they are hungrier at eating times and struggle the manage portions or may compensate the next day. In these cases, eating more regularly and portioning those options would be better suited.


IF may make weight loss easier for some, but more difficult for others. Unsurprisingly, it seems to come down to preference as IF stacks up comparably to standard calorie reduced diets for weight loss.

Chronic Diseases and Metabolic Markers

In studies looking at metabolic health including markers like glucose control, lipid profiles (including cholesterol and triglyceride levels), as well as blood pressure, improvements are often observed. The catch is, these improvements have not been found to be uniquely different to that of a calorie reduced diet.


These changes do relate to reducing risk of developing type 2 diabetes and heart disease (though only the factors that increase risk, not heart disease itself has been studied). As with weight loss however, the results of IF has resulted in comparable changes in these markers, not making it a superior option.


Interestingly, the value of eating in line with our circadian rhythm, which may follow an IF time restricted feeding pattern (finishing eating earlier in the day) has been associated with improvements in glucose control, reducing risk of Type 2 Diabetes, and lowering blood pressure. This evidence is not only IF-specific however, in that the area of ‘chrono nutrition’ is fast growing, which supports not eating into “biological night” and the associated risks of shift workers for developing chronic diseases like diabetes and heart disease.


When it comes to risk of type 2 diabetes and heart disease, following an IF-style diet may help in reducing overall risk, however, following general healthy eating principles in a calorie reduced diet can do the same, and may suit some better.

Ageing/Longevity

This is one of the most interesting and eye-catching arguments that IF supporters will make.


In animal studies, there is some evidence that any form of calorie restriction (including intermittent fasting) can result in slowing the ageing process and extend the lifespan. This is partially related to autophagy, a process triggering the body to bump up regenerative process of cell repair and recycling damaged cells. However, not only are these studies only applicable to the animal models they’ve been tested on, they also don’t apply exclusively to IF, but rather calorie reduced diets in general.


Really, far more research is required, not only in the “life extending” benefits that IF is so sought after for humans, but also in comparing IF and general calorie restriction for the same.

Digestive Health

The research in this area is even more limited than the others. Meaning: despite how it may be sold to you, there is nothing yet supporting IF to solve your digestive woes. In fact, it may worsen digestive issues like IBS with the possibility of larger meal sizes, FODMAP stacking and increased stresses around your food choices often being culprits for worsening symptoms.


Anecdotally, many who suffer from IBS-like symptoms including bloating and abdominal pain may report improvements when fasting. However, this may be due to removing common triggers, adjusting their meal timing or just an overall reduction in intake. There are many other options to trial before starting a restrictive diet.


In those with chronic conditions like Inflammatory Bowel Disease (IBD), there is already a risk of nutrient deficiencies and so, further limiting your nutrient intake, particularly during a flare could put you at greater risk here. When it comes to the microbiome itself, IF hasn’t been linked to significant changes, and so, again, this area would also need further research


If you have chronic digestive condition, IF may put you at risk of worsening symptoms and nutrient deficiencies. If it is something you would like to trial, I strongly encourage working with a Dietitian and your health care team here. Overall, there is much more evidence needed in this space to support the talk regarding IF and digestive health.

Nutrition

From a nutrition standpoint, it can be difficult to meet all your nutrient requirements consistently when following an IF pattern and having less eating occasions during the day. Many struggle to do this when eating “normally”, while this is further emphasised when in a calorie deficit and intake is restricted, so is not unique either.


IF doesn't specify your food choices and diet quality, and this is still an important consideration for health.


If looking to undertake an IF-style diet, I would recommend consulting with a health professional to guide you in planning your days.


Who shouldn't fast?

IF does not suit everyone, and that’s OK.


If you are pregnant or breastfeeding, have a history of disordered eating or a poor relationship with food, you are younger than 18 or older than 75, have a complex medical history or are on medications that may cause low blood sugar, then IF is not recommended for you.


If you have poor glycaemic control, fasting has been linked with worsened glucose response, instead having a steady intake through the day is more appropriate.

Finally, if you like breakfast, the idea of small, frequent meals or don’t like food rules…IF isn’t for you either. I think this is most important to consider. Even if there were evidence proving IF extended life a little, or made weight loss a little easier, if it does not suit you and makes your life very uncomfortable, there is no benefit and there are other options.

Summary

IF has been linked to reducing weight and the risk of chronic diseases like diabetes. However, this has not been found to be a superior method over general healthy eating and a calorie reduced diet.


As with any way of eating, which is very personal, it really seems to be suitable for some and not others. So, do whatever suits you best and keeps you well physically, mentally, and emotionally.


References

  1. Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., & Kiosses, W. B. (2010). Short-term fasting induces profound neuronal autophagy. Autophagy, 6(6), 702–710. https://doi.org/10.4161/auto.6.6.12376

  2. Conley M, Le Fevre L, Haywood C, Proietto J. Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet. 2018 Feb;75(1):65-72. doi: 10.1111/1747-0080.12372. Epub 2017 Aug 9. PMID: 28791787.

  3. Davis CS, Clarke RE, Coulter SN, Rounsefell KN, Walker RE, Rauch CE, Huggins CE, Ryan L. Intermittent energy restriction and weight loss: a systematic review. Eur J Clin Nutr. 2016 Mar;70(3):292-9. doi: 10.1038/ejcn.2015.195. Epub 2015 Nov 25. PMID: 26603882.

  4. Gabel K, Hoddy KK, Haggerty N, Song J, Kroeger CM, Trepanowski JF, Panda S, Varady KA. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutr Healthy Aging. 2018 Jun 15;4(4):345-353. doi: 10.3233/NHA-170036. PMID: 29951594; PMCID: PMC6004924.

  5. Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018 Jul 9;10(7):e2947. doi: 10.7759/cureus.2947. PMID: 30202677; PMCID: PMC6128599.

  6. Geliebter A, Astbury NM, Aviram-Friedman R, Yahav E, Hashim S. Skipping breakfast leads to weight loss but also elevated cholesterol compared with consuming daily breakfasts of oat porridge or frosted cornflakes in overweight individuals: a randomised controlled trial. J Nutr Sci. 2014 Nov 13;3:e56. doi: 10.1017/jns.2014.51. PMID: 26101624; PMCID: PMC4473164.

  7. Gill S, Panda S. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits. Cell Metab. 2015 Nov 3;22(5):789-98. doi: 10.1016/j.cmet.2015.09.005. Epub 2015 Sep 24. PMID: 26411343; PMCID: PMC4635036.

  8. Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, Son TG, Maudsley S, Carlson OD, Egan JM, Flyvbjerg A, Howell A. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond). 2011 May;35(5):714-27. doi: 10.1038/ijo.2010.171. Epub 2010 Oct 5. PMID: 20921964; PMCID: PMC3017674.

  9. Headland M, Clifton PM, Carter S, Keogh JB. Weight-Loss Outcomes: A Systematic Review and Meta-Analysis of Intermittent Energy Restriction Trials Lasting a Minimum of 6 Months. Nutrients. 2016 Jun 8;8(6):354. doi: 10.3390/nu8060354. PMID: 27338458; PMCID: PMC4924195.

  10. Hoddy KK, Kroeger CM, Trepanowski JF, Barnosky A, Bhutani S, Varady KA. Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults. Obesity (Silver Spring). 2014 Dec;22(12):2524-31. doi: 10.1002/oby.20909. Epub 2014 Sep 24. Erratum in: Obesity (Silver Spring). 2015 Apr;23(4):914. PMID: 25251676.

  11. Horne BD, Muhlestein JB, Anderson JL. Health effects of intermittent fasting: hormesis or harm? A systematic review. Am J Clin Nutr. 2015 Aug;102(2):464-70. doi: 10.3945/ajcn.115.109553. Epub 2015 Jul 1. PMID: 26135345.

  12. Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LK. Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. Obesity (Silver Spring). 2019 May;27(5):724-732. doi: 10.1002/oby.22449. Epub 2019 Apr 19. PMID: 31002478.

  13. Jakubowicz D, Wainstein J, Ahren B, Landau Z, Bar-Dayan Y, Froy O. Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial. Diabetes Care. 2015 Oct;38(10):1820-6. doi: 10.2337/dc15-0761. Epub 2015 Jul 28. PMID: 26220945.

  14. Kesztyüs D, Cermak P, Gulich M, Kesztyüs T. Adherence to Time-Restricted Feeding and Impact on Abdominal Obesity in Primary Care Patients: Results of a Pilot Study in a Pre-Post Design. Nutrients. 2019 Nov 21;11(12):2854. doi: 10.3390/nu11122854. PMID: 31766465; PMCID: PMC6950236.

  15. Krista A Varady, Marc K Hellerstein, Alternate-day fasting and chronic disease prevention: a review of human and animal trials, The American Journal of Clinical Nutrition, Volume 86, Issue 1, July 2007, Pages 7–13, https://doi.org/10.1093/ajcn/86.1.7

  16. Lettieri-Barbato, D., Giovannetti, E., & Aquilano, K. (2016). Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human. Aging, 8(12), 3341–3355. https://doi.org/10.18632/aging.101122

  17. Levenson CW, Rich NJ. Eat less, live longer? New insights into the role of caloric restriction in the brain. Nutr Rev. 2007 Sep;65(9):412-5. doi: 10.1111/j.1753-4887.2007.tb00319.x. PMID: 17958208.

  18. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. PMID: 25902704; PMCID: PMC4531065.

  19. Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, Philip E, Vittinghoff E, Heymsfield SB, Olgin JE, Shepherd JA, Weiss EJ. Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial. JAMA Intern Med. 2020 Nov 1;180(11):1491-1499. doi: 10.1001/jamainternmed.2020.4153. Erratum in: JAMA Intern Med. 2020 Nov 1;180(11):1555. Erratum in: JAMA Intern Med. 2021 Jun 1;181(6):883. PMID: 32986097; PMCID: PMC7522780.

  20. Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S. Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. Cell Metab. 2016 Apr 12;23(4):591-601. doi: 10.1016/j.cmet.2016.02.005. Epub 2016 Feb 22. PMID: 26916363; PMCID: PMC4833627.

  21. Martin, B., Mattson, M. P., & Maudsley, S. (2006). Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing research reviews, 5(3), 332–353. https://doi.org/10.1016/j.arr.2006.04.002

  22. Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. PMID: 27810402; PMCID: PMC5411330.

  23. Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev. 2012 Jul;11(3):390-8. doi: 10.1016/j.arr.2011.11.005. Epub 2011 Dec 20. PMID: 22210414; PMCID: PMC3356510.

  24. Moro T, Tinsley G, Bianco A, Marcolin G, Pacelli QF, Battaglia G, Palma A, Gentil P, Neri M, Paoli A. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016 Oct 13;14(1):290. doi: 10.1186/s12967-016-1044-0. PMID: 27737674; PMCID: PMC5064803.

  25. Stratton MT, Tinsley GM, Alesi MG, Hester GM, Olmos AA, Serafini PR, Modjeski AS, Mangine GT, King K, Savage SN, Webb AT, VanDusseldorp TA. Four Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood Biomarkers. Nutrients. 2020 Apr 17;12(4):1126. doi: 10.3390/nu12041126. PMID: 32316561; PMCID: PMC7231047.

  26. Sundfør TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial. Nutr Metab Cardiovasc Dis. 2018 Jul;28(7):698-706. doi: 10.1016/j.numecd.2018.03.009. Epub 2018 Mar 29. PMID: 29778565.

  27. Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev. 2015 Oct;73(10):661-74. doi: 10.1093/nutrit/nuv041. Epub 2015 Sep 15. PMID: 26374764.

  28. Tinsley GM, Moore ML, Graybeal AJ, Paoli A, Kim Y, Gonzales JU, Harry JR, VanDusseldorp TA, Kennedy DN, Cruz MR. Time-restricted feeding plus resistance training in active females: a randomized trial. Am J Clin Nutr. 2019 Sep 1;110(3):628-640. doi: 10.1093/ajcn/nqz126. PMID: 31268131; PMCID: PMC6735806.

  29. Trepanowski JF, Kroeger CM, Barnosky A, Klempel MC, Bhutani S, Hoddy KK, Gabel K, Freels S, Rigdon J, Rood J, Ravussin E, Varady KA. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Jul 1;177(7):930-938. doi: 10.1001/jamainternmed.2017.0936. PMID: 28459931; PMCID: PMC5680777.

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